| pubmed-article:8151786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0017280 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:8151786 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:8151786 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8151786 | pubmed:dateCreated | 1994-5-12 | lld:pubmed |
| pubmed-article:8151786 | pubmed:abstractText | Human immunodeficiency virus type 1 (HIV-1) negative factor (Nef) has been shown to down-regulate the transcription factors NF-kappa B and AP-1 in vitro. To define the mechanism of action of the Nef protein, the signal transduction pathways which may be affected in T cells by constitutive expression of the nef gene were examined. Stimulation of T cells with tumor necrosis factor, interleukin-1, or lipopolysaccharide resulted in the recruitment of transcriptional factors to a similar level whether or not the cells expressed the nef gene. On the other hand, stimulation of T cells by mitogens or antibodies to the T-cell receptor (TCR)-CD3 complex resulted in the down-regulation of transcriptional factors NF-kappa B and AP-1 in cells expressing the nef gene compared with cells not expressing the nef gene. Because the Nef protein does not affect the surface expression of the CD3-TCR complex, we conclude that the Nef protein down-regulates the transcriptional factors NF-kappa B and AP-1 in T cells in vitro through an effect on the TCR-dependent signal transduction pathway. | lld:pubmed |
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| pubmed-article:8151786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8151786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8151786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8151786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8151786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8151786 | pubmed:month | May | lld:pubmed |
| pubmed-article:8151786 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:8151786 | pubmed:author | pubmed-author:RatnerLL | lld:pubmed |
| pubmed-article:8151786 | pubmed:author | pubmed-author:BandresJ CJC | lld:pubmed |
| pubmed-article:8151786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8151786 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:8151786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8151786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8151786 | pubmed:pagination | 3243-9 | lld:pubmed |
| pubmed-article:8151786 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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