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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-5-10
|
| pubmed:abstractText |
In 1983, a cohort study to follow up the family contacts of leprosy cases was implemented in French Polynesia to assess the usefulness and applicability of phenolic glycolipid-I (PGL-I) serology in a leprosy control program. A total of 1201 contacts (666 females, 535 males) have been included in the study. The IgM anti-PGL-I seroprevalence determined on the initial sera was 17%. It was significantly higher among females than males (20% vs 15%, p = 0.02). From 1983 to 1992, 4 out of 204 (2%) anti-PGL-I seropositive contacts developed the disease (1 indeterminate, 1 BT, 1 BL, 1 LL) compared with 10 out of 997 (1%) seronegative contacts (4 indeterminate, 3 BT, 1 BB, 2 TT). Of these 10 patients, only 3 (2 indeterminate, 1 BT) converted to seropositivity when leprosy was diagnosed. The risk of developing leprosy was not significantly higher among seropositive than among seronegative groups (2% vs 1%, p = 0.2). A PGL-I circulating antigen test performed on 216 selected sera at entry into the trial showed a higher antigen prevalence when the antibody level was higher. PGL-I antigen was detectable in 5 of 12 patients tested prior to diagnosis (1 LL, 1 BL, 3 indeterminate). The median time to externalize the disease was not significantly different among antibody-positive and -negative contacts (17 vs 25 months, p = 0.3). The relative risk of developing leprosy for contact individuals was 30.8 times that of noncontacts, and 15% of the total new cases detected between 1983 and 1992 emerged from the study population.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0148-916X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
533-41
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8151183-Adolescent,
pubmed-meshheading:8151183-Adult,
pubmed-meshheading:8151183-Age Distribution,
pubmed-meshheading:8151183-Antibodies, Bacterial,
pubmed-meshheading:8151183-Antigens, Bacterial,
pubmed-meshheading:8151183-Child,
pubmed-meshheading:8151183-Child, Preschool,
pubmed-meshheading:8151183-Cohort Studies,
pubmed-meshheading:8151183-Family,
pubmed-meshheading:8151183-Female,
pubmed-meshheading:8151183-Follow-Up Studies,
pubmed-meshheading:8151183-Glycolipids,
pubmed-meshheading:8151183-Humans,
pubmed-meshheading:8151183-Incidence,
pubmed-meshheading:8151183-Infant,
pubmed-meshheading:8151183-Infant, Newborn,
pubmed-meshheading:8151183-Leprosy,
pubmed-meshheading:8151183-Male,
pubmed-meshheading:8151183-Middle Aged,
pubmed-meshheading:8151183-Mycobacterium leprae,
pubmed-meshheading:8151183-Polynesia,
pubmed-meshheading:8151183-Predictive Value of Tests,
pubmed-meshheading:8151183-Prevalence,
pubmed-meshheading:8151183-Prospective Studies,
pubmed-meshheading:8151183-Risk Factors,
pubmed-meshheading:8151183-Sex Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Low predictive value of PGL-I serology for the early diagnosis of leprosy in family contacts: results of a 10-year prospective field study in French Polynesia.
|
| pubmed:affiliation |
Institut de Recherches Médicales Louis Malardé, Papéete, Tahiti, French Polynésia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|