Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-12
pubmed:abstractText
Antigen-driven responses by T cells from patients with CVID and normal subjects have been assessed. Low-density cells enriched for antigen-presenting dendritic cells were cultured with T cells using a 20-microliters hanging drop system. T cells from all subgroups of CVID patients showed markedly reduced responses to the recall antigens purified protein derivative (PPD) or tetanus toxoid, whereas responses by cells from patients with X-linked agammaglobulinaemia, used as a disease control, were in the normal range. However, primary allo-stimulation of CVID T cells was normal. CVID cells from two patients failed to respond to stimulation with a neoantigen, an HIV env peptide, under conditions where normal T cells did respond. These data illustrate a profound defect in antigen-stimulated T cell proliferation in vitro in all groups of CVID patients, but do not distinguish whether the defect is in the presenting cell or in the T lymphocyte. In vivo, germinal centre B cells are thought to present antigen to primed T cells to obtain essential signals (e.g. CD40 ligand and IL-2) for B cell survival and progression to immunoglobulin secretion. A failure of antigen-specific T cell function in vivo in CVID would thus not provide the primed T cells needed for B cell rescue, and could be the primary defect leading to the low immunoglobulin production in this condition.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1085784, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1458779, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1510837, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1534309, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1666628, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1769689, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1804777, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1826647, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1863999, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-1991850, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2025614, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2078333, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2110212, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2165880, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2472237, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-2784483, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-3007336, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-3111766, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-3529367, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-3876180, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-4549712, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-6213861, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-6611349, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-7039882, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-7049463, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-7373063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8149665-7679424
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-53
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID).
pubmed:affiliation
Antigen Presentation Group, Clinical Research Centre, Harrow, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't