Linked Life Data

8141289

Source:http://linkedlifedata.com/resource/pubmed/id/8141289

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1994-4-28
pubmed:abstractText
Complex interactions between the enteric nervous system, the immune system, and the epithelium govern the transport rates of salt and water across the intestinal lining. Luminal antigens or bacterial products are detected by the immune system, which triggers a cascade of events associated with the release of inflammatory mediators. These mediators, by lowering the response threshold for transmission in some neural circuits, augment ongoing neural reflexes that promote secretion. Associated with these effects is a dampening of responses in other neural circuits innervating the mucosal effectors. Selective excitation and inhibition of the neural reflex circuitry coupled with direct actions of inflammatory mediators on epithelial cells result in stereotypical motility and secretory patterns that are characterized by strong muscular contractions, copious secretion, and diarrhea.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
G167-78
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Neuroimmune signaling in regulation of intestinal ion transport.
pubmed:affiliation
Department of Physiology, Ohio State University, Columbus 43210.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review