Linked Life Data

8138720

Source:http://linkedlifedata.com/resource/pubmed/id/8138720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-25
pubmed:abstractText
Sonication of rat fat cells caused an increase in lipolysis in the absence of lipolytic stimulants (basal lipolysis) and loss of epinephrine responsiveness. Sonication of endogenous lipid droplets from fat cells also induced an increase in lipolysis in the presence of hormone-sensitive lipase (HSL) and loss of epinephrine responsiveness in a cell-free system consisting of lipid droplets and HSL. This increase in lipolysis was found not to be due to an increase in the surface area resulting from sonication, but seemed to be due to a decrease in the phosphatidylcholine concentration on the surface of the lipid droplets. Addition of phosphatidylcholine to the sonicated lipid droplets reduced the hydrolysis of triglyceride by HSL in the cell-free system, consisting of HSL and intact lipid droplets or a lipid emulsion containing phosphatidylcholine increased lipolysis. These results suggest that phosphatidylcholine on the surface of the lipid droplets may be a regulatory factor for lipolysis in fat cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
36-44
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Role of endogenous lipid droplets in lipolysis in rat adipocytes.
pubmed:affiliation
2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Japan.
pubmed:publicationType
Journal Article, In Vitro