Linked Life Data

8132173

Source:http://linkedlifedata.com/resource/pubmed/id/8132173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-4-19
pubmed:abstractText
Topical exposure to many occupational and environmental chemicals is often accompanied by the induction of a cutaneous inflammatory response characterized by the influx of polymorphonuclear leucocytes (PMNs). In this study, the accumulation of myeloperoxidase (MPO), an enzyme found at high content in PMNs, was used as a biomarker to assess the inflammatory response to a number of well characterized skin irritants and tumour promoters. Of the chemicals examined, there was a good agreement between MPO accumulation and morphometric indicators of PMNs. Therefore, it was suggested that MPO accumulation could be an additional and useful toxicological tool for determining the dermal irritancy of chemicals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0278-6915
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Myeloperoxidase as a biomarker of skin irritation and inflammation.
pubmed:affiliation
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't