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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-4-12
|
| pubmed:abstractText |
A regio and stereospecific synthesis of 2-methyl-(Z)-4-(phenylimino)naphth[2,3-d]oxazol-9-one (1) was achieved by using titanium tetrachloride in methylene chloride in the preparation of the imine. The regiochemistry was assigned by single-crystal X-ray analysis. In vitro tests showed that this diastereomer is selectively active for some solid cancer tumors.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
710-2
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8126711-Antineoplastic Agents,
pubmed-meshheading:8126711-Crystallography, X-Ray,
pubmed-meshheading:8126711-Humans,
pubmed-meshheading:8126711-Imines,
pubmed-meshheading:8126711-Molecular Structure,
pubmed-meshheading:8126711-Oxazoles,
pubmed-meshheading:8126711-Stereoisomerism,
pubmed-meshheading:8126711-Tumor Cells, Cultured
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Synthesis of 2-methyl-(Z)-4-(phenylimino)naphth[2,3-d]oxazol-9-one , a monoimine quinone with selective cytotoxicity toward cancer cells.
|
| pubmed:affiliation |
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta 30332.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|