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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6464
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pubmed:dateCreated |
1994-3-23
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pubmed:databankReference | |
pubmed:abstractText |
Protein translocation into the mammalian endoplasmic reticulum requires the Sec61p complex, which consists of three membrane proteins. The alpha-subunit, the homologue of Sec61p of yeast, shows some similarity to SecYp, a key component of the protein export apparatus of bacteria. In Escherichia coli, SecYp is also associated with two other proteins (SecEp and band-1 protein). We have now determined the sequences of the beta- and gamma-subunits of the mammalian Sec61p complex. Sec61-gamma is homologous to SSS1p, a suppressor of sec61 mutants in Saccharomyces cerevisiae, and can functionally replace it in yeast cells. Moreover, Sec61-gamma and SSS1p are structurally related to SecEp of E. coli and to putative homologues in various other bacteria. At least two subunits of the Sec61/SecYp complex therefore seem to be key components of the protein translocation apparatus in all classes of organisms.
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
367
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
654-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8107851-Amino Acid Sequence,
pubmed-meshheading:8107851-Animals,
pubmed-meshheading:8107851-Base Sequence,
pubmed-meshheading:8107851-Biological Transport,
pubmed-meshheading:8107851-Conserved Sequence,
pubmed-meshheading:8107851-Dogs,
pubmed-meshheading:8107851-Eukaryotic Cells,
pubmed-meshheading:8107851-Humans,
pubmed-meshheading:8107851-Membrane Proteins,
pubmed-meshheading:8107851-Molecular Sequence Data,
pubmed-meshheading:8107851-Mutation,
pubmed-meshheading:8107851-Prokaryotic Cells,
pubmed-meshheading:8107851-Proteins,
pubmed-meshheading:8107851-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Evolutionary conservation of components of the protein translocation complex.
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pubmed:affiliation |
Max-Delbrück Centre for Molecular Medicine, Berlin-Buch, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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