| pubmed-article:8104472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0006304 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C1333196 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:8104472 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:8104472 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:8104472 | pubmed:dateCreated | 1993-10-28 | lld:pubmed |
| pubmed-article:8104472 | pubmed:abstractText | Immunization of BALB/c mice with killed Brucella abortus (BA) has previously been shown to increase serum IgG2a levels and long-term T cell clones from these mice secrete Th1-associated cytokines: IFN-gamma and IL-2 but not IL-4 or IL-5. We analyzed cytokine gene expression following primary immunization with BA to determine when CD4+ T cells first express cytokine genes and whether specific hypothesized cytokine patterns (e.g. Th precursor, Th0) could be identified prior to a Th1-like pattern. Our results demonstrated a highly consistent and novel pattern of Th1/Th2 cytokine gene expression characterized by elevated IL-10 and IFN-gamma in CD4+ T cells which rapidly manifests itself and is sustained for at least 10 days after immunization. No elevation in IL-2 cytokine gene expression was observed and treatment of BA-immunized mice with blocking anti-IL-2 antibodies had no effect on the cytokine gene expression pattern, although treatment with anti-IFN antibodies resulted in increased IL-4, IL-5, and IL-9 cytokine gene expression, in the absence of any change in IFN-gamma or IL-10 as early as 4 days after immunization. These results suggest that a whole pathogen may trigger sufficient costimulatory signals to rapidly induce effector T cells in the absence of elevated IL-2 and that IL-10 is specifically elevated in certain Th1-like responses. | lld:pubmed |
| pubmed-article:8104472 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8104472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8104472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8104472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8104472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8104472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8104472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8104472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8104472 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8104472 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:8104472 | pubmed:author | pubmed-author:FinkelmanF... | lld:pubmed |
| pubmed-article:8104472 | pubmed:author | pubmed-author:LuPP | lld:pubmed |
| pubmed-article:8104472 | pubmed:author | pubmed-author:GauseW CWC | lld:pubmed |
| pubmed-article:8104472 | pubmed:author | pubmed-author:Sveti?AA | lld:pubmed |
| pubmed-article:8104472 | pubmed:author | pubmed-author:JianY CYC | lld:pubmed |
| pubmed-article:8104472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8104472 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8104472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8104472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8104472 | pubmed:pagination | 877-83 | lld:pubmed |
| pubmed-article:8104472 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:8104472 | pubmed:meshHeading | pubmed-meshheading:8104472-... | lld:pubmed |
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| pubmed-article:8104472 | pubmed:meshHeading | pubmed-meshheading:8104472-... | lld:pubmed |
| pubmed-article:8104472 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8104472 | pubmed:articleTitle | Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells. | lld:pubmed |
| pubmed-article:8104472 | pubmed:affiliation | Department of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. | lld:pubmed |
| pubmed-article:8104472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8104472 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8104472 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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