Linked Life Data

8103145

Source:http://linkedlifedata.com/resource/pubmed/id/8103145

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8872
pubmed:dateCreated
1993-9-27
pubmed:abstractText
To compare octreotide with injection sclerotherapy in the treatment of acute variceal haemorrhage, patients admitted with gastrointestinal bleeding and oesophageal varices confirmed by endoscopy were randomised to receive either emergency sclerotherapy with 3% sodium tetradecyl sulphate or octreotide (50 micrograms intravenous bolus plus 50 micrograms per h intravenous infusion for 48 h). At the end of the study period (48 h), the octreotide group also had sclerotherapy to obliterate the varices. 100 patients were recruited. Demographic features including the aetiology of portal hypertension and the Child-Pugh's grading of the two groups were similar. Bleeding was initially controlled in 90% of patients by emergency sclerotherapy and in 84% by octreotide infusion (95% confidence interval 0-19.5, p = 0.55). There were no significant differences between the two groups in early (within 48 h of randomisation) rebleeding (16% vs 14%), blood transfusion (3 units vs 3.5), hospital stay (5 days vs 6 days), or hospital mortality (27% vs 20%). No notable side-effects were associated with octreotide. We conclude that octreotide infusion and emergency sclerotherapy are equally effective in controlling variceal haemorrhage.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
342
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
637-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8103145-Adolescent, pubmed-meshheading:8103145-Adult, pubmed-meshheading:8103145-Aged, pubmed-meshheading:8103145-Emergencies, pubmed-meshheading:8103145-Esophageal and Gastric Varices, pubmed-meshheading:8103145-Esophagoscopy, pubmed-meshheading:8103145-Female, pubmed-meshheading:8103145-Follow-Up Studies, pubmed-meshheading:8103145-Gastrointestinal Hemorrhage, pubmed-meshheading:8103145-Hospital Mortality, pubmed-meshheading:8103145-Humans, pubmed-meshheading:8103145-Injections, Intravenous, pubmed-meshheading:8103145-Length of Stay, pubmed-meshheading:8103145-Male, pubmed-meshheading:8103145-Middle Aged, pubmed-meshheading:8103145-Octreotide, pubmed-meshheading:8103145-Recurrence, pubmed-meshheading:8103145-Sclerotherapy, pubmed-meshheading:8103145-Sodium Tetradecyl Sulfate, pubmed-meshheading:8103145-Treatment Outcome
pubmed:year
1993
pubmed:articleTitle
Octreotide infusion or emergency sclerotherapy for variceal haemorrhage.
pubmed:affiliation
Department of Medicine, Prince of Wales Hospital, Chinese University of Hong Kong.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial