Linked Life Data

8100458

Source:http://linkedlifedata.com/resource/pubmed/id/8100458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1993-8-5
pubmed:abstractText
Urodilatin is found in the urine and is thought to be produced in the kidney. The effect of urodilatin on cGMP accumulation in the kidney was investigated. cGMP accumulation by urodilatin and atrial natriuretic peptide (ANP) were compared with tubule suspensions from renal cortex, outer medulla, inner medulla, and microdissected nephron segments. Urodilatin-stimulated cGMP accumulation was higher in tubule suspensions from the inner medulla than in those from the cortex and outer medulla. The highest accumulation stimulated by 10(-6) M urodilatin among nephron segments was observed in glomeruli and inner medullary collecting ducts (IMCD). Small accumulations were seen in proximal convoluted tubules and medullary thick ascending limbs. Urodilatin-stimulated cGMP accumulation was almost equal to that stimulated by the same concentrations of ANP in these nephron segments. Urodilatin (10(-8) M) did not stimulate cGMP accumulation in glomeruli, but it stimulated cGMP accumulation in IMCD by threefold. This pattern was quite similar to that with ANP. It was concluded that urodilatin has a similar ability to ANP in stimulating cGMP synthesis and that the main target sites are glomeruli and IMCD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1705-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of urodilatin on cGMP accumulation in the kidney.
pubmed:affiliation
Second Department of Internal Medicine, Tokyo Medical & Dental University, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't