Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1993-7-19
|
| pubmed:abstractText |
A sensitive C-peptide immunoreactivity radioimmunoassay demonstrated the presence of subtle, but definite residual beta-cell function in patients with IDDM of long duration. Although HLA antigens are known to influence susceptibility to IDDM, their contribution to the extent of pancreatic beta-cell destruction has not yet been examined extensively. We studied the relationship between residual beta-cell function and HLA class I and class II antigens in 111 unrelated Japanese IDDM patients. Using the sensitive C-peptide immunoreactivity radioimmunoassay, the presence or absence of residual beta-cell function was evaluated by the C-peptide immunoreactivity response to a 100-g oral glucose load. DNA typing for HLA-DQA1 and HLA-DQB1 antigens was performed in addition to serological typing of HLA-A, HLA-B, HLA-C, and HLA-DR antigens. A C-peptide immunoreactivity response > 0.033 nM was regarded as an indication of the presence of residual beta-cell function, not the assay error. Surprisingly, 35 of 37 (94.6%) patients without residual beta-cell function had HLA-A24, whereas only 39 of 74 (52.7%) patients with residual beta-cell function had this antigen (corrected P = 9.795 x 10(-6). Any other HLA antigens, including the DR and DQ loci, showed no difference in the frequency with regard to residual beta-cell function. The duration of diabetes was similar between the groups with and without residual beta-cell function.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A24 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
42
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1086-93
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8099884-Adolescent,
pubmed-meshheading:8099884-Adult,
pubmed-meshheading:8099884-Alleles,
pubmed-meshheading:8099884-Base Sequence,
pubmed-meshheading:8099884-C-Peptide,
pubmed-meshheading:8099884-Child,
pubmed-meshheading:8099884-Diabetes Mellitus, Type 1,
pubmed-meshheading:8099884-Female,
pubmed-meshheading:8099884-Glucose Tolerance Test,
pubmed-meshheading:8099884-HLA-A Antigens,
pubmed-meshheading:8099884-HLA-A24 Antigen,
pubmed-meshheading:8099884-HLA-DQ Antigens,
pubmed-meshheading:8099884-Histocompatibility Testing,
pubmed-meshheading:8099884-Humans,
pubmed-meshheading:8099884-Islets of Langerhans,
pubmed-meshheading:8099884-Male,
pubmed-meshheading:8099884-Middle Aged,
pubmed-meshheading:8099884-Molecular Sequence Data,
pubmed-meshheading:8099884-Oligodeoxyribonucleotides,
pubmed-meshheading:8099884-Polymerase Chain Reaction,
pubmed-meshheading:8099884-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:8099884-Radioimmunoassay,
pubmed-meshheading:8099884-Reference Values
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Association of HLA-A24 with complete beta-cell destruction in IDDM.
|
| pubmed:affiliation |
Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|