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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5105
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pubmed:dateCreated |
1993-5-10
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pubmed:abstractText |
Calcium ions (Ca2+) act as an intracellular second messenger and can enter neurons through various ion channels. Influx of Ca2+ through distinct types of Ca2+ channels may differentially activate biochemical processes. N-Methyl-D-aspartate (NMDA) receptors and L-type Ca2+ channels, two major sites of Ca2+ entry into hippocampal neurons, were found to transmit signals to the nucleus and regulated gene transcription through two distinct Ca2+ signaling pathways. Activation of the multifunctional Ca(2+)-calmodulin-dependent protein kinase (CaM kinase) was evoked by stimulation of either NMDA receptors or L-type Ca2+ channels; however, activation of CaM kinase appeared to be critical only for propagating the L-type Ca2+ channel signal to the nucleus. Also, the NMDA receptor and L-type Ca2+ channel pathways activated transcription by means of different cis-acting regulatory elements in the c-fos promoter. These results indicate that Ca2+, depending on its mode of entry into neurons, can activate two distinct signaling pathways. Differential signal processing may provide a mechanism by which Ca2+ controls diverse cellular functions.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Response Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
260
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pubmed:geneSymbol |
c-fos
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
181-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8097060-Animals,
pubmed-meshheading:8097060-Calcium,
pubmed-meshheading:8097060-Calcium Channels,
pubmed-meshheading:8097060-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8097060-Cells, Cultured,
pubmed-meshheading:8097060-DNA-Binding Proteins,
pubmed-meshheading:8097060-Gene Expression Regulation,
pubmed-meshheading:8097060-Genes, fos,
pubmed-meshheading:8097060-Glutamates,
pubmed-meshheading:8097060-Glutamic Acid,
pubmed-meshheading:8097060-Hippocampus,
pubmed-meshheading:8097060-Neurons,
pubmed-meshheading:8097060-Nuclear Proteins,
pubmed-meshheading:8097060-Protein Kinases,
pubmed-meshheading:8097060-Rats,
pubmed-meshheading:8097060-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:8097060-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8097060-Second Messenger Systems,
pubmed-meshheading:8097060-Serum Response Factor,
pubmed-meshheading:8097060-Signal Transduction,
pubmed-meshheading:8097060-Transcription Factors,
pubmed-meshheading:8097060-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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