Linked Life Data

80864

Source:http://linkedlifedata.com/resource/pubmed/id/80864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1978-11-18
pubmed:abstractText
Drawing a line more intelligently for AFP data means using as a denominator two fairly well-defined populations (abnormal and normal), instead of one ill-defined normal population. The line is drawn at the intersect between two curves to minimize the error of misclassification; this replaces an arbitrarily defined cutoff level (multiples of the standard deviation unit). Moving the line to the right reduces the false positive error when screening for NTD, whereas moving the line to the left provides a sensitive alert signal for routine screening of maternal sera by AFP determinations for fetal distress. Adjustment of the line for cost and benefit factors and the use of probability statements that include the prevalence of specific conditions all help sharpen medical classification and decisions. Cross-sectional analysis is separated from longitudinal analysis. A benefit from this discussion may be the replacement of the normal range with a simple plot of AFP results or a percentile distribution, which would be more meaningful and more easily understood by all.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0082-7134
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-34
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Pitfalls and problems in the interpretation of AFP data--myths and misuse of the "normal range".
pubmed:publicationType
Journal Article