Linked Life Data

8083736

Source:http://linkedlifedata.com/resource/pubmed/id/8083736

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1994-10-12
pubmed:abstractText
Recent studies showed that brain-derived neurotrophic factor (BDNF) prevents developing motoneurons from naturally occurring and axotomy-induced cell death. Here we examined whether adult motoneurons retain responsiveness to BDNF. Consistent with previous studies, we found that adult spinal and brainstem motoneurons expressed the mRNA of BDNF receptor, trkB. In addition, the trkB immunoreactivities were readily detected in the adult spinal and brainstem motoneurons. We then demonstrated that axotomized adult motoneurons responded to exogenous BDNF. BDNF administered locally markedly attenuated the lesion-induced decrease of ChAT immunoreactivity and activity and enhanced the lesion-induced reexpression of low-affinity NGF receptor immunoreactivity in adult facial motoneurons. Furthermore, we found BDNF administered subcutaneously, intravenously, and into the cerebral ventricle attenuated the lesion-induced decrease of ChAT immunoreactivity in adult facial motoneurons in a dose-dependent fashion. Our data indicate that adult motoneurons retain their responsiveness to BDNF, suggesting that BDNF may be useful as a therapeutic agent for adult motoneuron disease.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5281-91
pubmed:dateRevised
2008-10-16
pubmed:meshHeading
pubmed-meshheading:8083736-Animals, pubmed-meshheading:8083736-Axons, pubmed-meshheading:8083736-Body Weight, pubmed-meshheading:8083736-Brain-Derived Neurotrophic Factor, pubmed-meshheading:8083736-Denervation, pubmed-meshheading:8083736-Dose-Response Relationship, Drug, pubmed-meshheading:8083736-Facial Nerve, pubmed-meshheading:8083736-Injections, Intravenous, pubmed-meshheading:8083736-Injections, Intraventricular, pubmed-meshheading:8083736-Injections, Subcutaneous, pubmed-meshheading:8083736-Motor Neurons, pubmed-meshheading:8083736-Nerve Growth Factors, pubmed-meshheading:8083736-Nerve Tissue Proteins, pubmed-meshheading:8083736-Rats, pubmed-meshheading:8083736-Rats, Sprague-Dawley, pubmed-meshheading:8083736-Receptor, Ciliary Neurotrophic Factor, pubmed-meshheading:8083736-Receptors, Nerve Growth Factor
pubmed:year
1994
pubmed:articleTitle
The biological responses of axotomized adult motoneurons to brain-derived neurotrophic factor.
pubmed:affiliation
Department of Neurobiology, Amgen, Inc., Amgen Center, Thousand Oaks, CA 91320.
pubmed:publicationType
Journal Article, Comparative Study