Linked Life Data

8080930

Source:http://linkedlifedata.com/resource/pubmed/id/8080930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-10-11
pubmed:abstractText
A series of segmented polydimethylsiloxane (PDMS) polyurea-urethanes was synthesized based on hexane diisocyanate modified polyether-PDMS soft segments. The hard segments consisted of 4,4'-methylene diphenylene diisocyanate, which was chain extended with 1,4-butanediol. The effect of chemical composition of the polyether-PDMS soft segments on the extent of phase separation, physical properties and surface properties was studied using a variety of techniques including dynamic mechanical analysis, tensile testing, X-ray photoelectron spectroscopy (XPS) and contact angle analysis. The polymers were also evaluated for their blood-contacting properties in a canine ex vivo model. The PDMS polyurea-urethanes containing polyether-PDMS soft segments showed three distinct phases: a PDMS-rich phase, a polyol soft segment-rich phase and a hard segment-rich phase. The tensile strength and modulus of these materials were not significantly lower compared to a polymer without PDMS in the soft segment. XPS revealed the surface enrichment of the hydrophobic PDMS component at the air-solid interface. Dynamic contact angle measurements indicated that the PDMS-based polyurea-urethanes possessed a hydrophobic surface in water. The PDMS polyurea-urethanes showed lower adherent platelet and fibrinogen deposition compared to a polymer without PDMS in the soft segment. Varying the amount of PDMS in the soft segment of these polymers did not reveal significant differences in their blood-contacting properties.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
408-16
pubmed:dateRevised
2009-2-7
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Synthesis, characterization and ex vivo evaluation of polydimethylsiloxane polyurea-urethanes.
pubmed:affiliation
University of Wisconsin-Madison, Department of Chemical Engineering 53706.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.