Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-10-4
|
| pubmed:abstractText |
Procollagen type 1 is mainly synthesized by osteoblasts and, after cleavage of the N- and C-terminal extension peptides, is utilized for collagen fibril deposition in the osteoid tissue. Serum levels of C-terminal extension peptide (Pcoll-1-C) of the procollagen molecule has been considered a useful marker for the evaluation of the rate of osteoblastic procollagen synthesis. To appraise whether in vivo parathyroid hormone (PTH) plays a suppressive role in the synthesis of procollagen type 1, a study has been carried out in 16 patients, 10 with severe secondary hyperparathyroidism of chronic renal failure and 6 with primary hyperparathyroidism. Following parathyroidectomy (PTX), in chronic renal failure patients a 94% fall in serum intact iPTH and a decline of serum calcium to hypocalcemic levels requiring calcitriol administration were observed. Serum Pcoll-1-C increased markedly with a peak after 7 days and a subsequent decline. Similar changes were observed for alkaline phosphatase and osteocalcin. In primary hyperparathyroidism, PTX was followed by an 88% drop in iPTH and mild hypocalcemia not requiring calcitriol administration. Also in this group serum Pcoll-1-C increased significantly with the same time course, unaccompanied by changes in alkaline phosphatase and osteocalcin. In 4 unsuccessfully neck-operated control patients no change in serum Pcoll-1-C levels was recorded during a period of 2 weeks postoperatively. In conclusion, acute withholding of parathyroid hypersecretion is accompanied by an abrupt and transitory increase of serum Pcoll-1-C, not dependent on calcitriol administration. Hypocalcemia following PTX may in part be due to uncoupling of bone formation and resorption.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitriol,
http://linkedlifedata.com/resource/pubmed/chemical/Osteocalcin,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen,
http://linkedlifedata.com/resource/pubmed/chemical/procollagen type I carboxy...
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0250-8095
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
106-12
|
| pubmed:dateRevised |
2007-2-14
|
| pubmed:meshHeading |
pubmed-meshheading:8080002-Adult,
pubmed-meshheading:8080002-Aged,
pubmed-meshheading:8080002-Alkaline Phosphatase,
pubmed-meshheading:8080002-Biological Markers,
pubmed-meshheading:8080002-Calcitriol,
pubmed-meshheading:8080002-Chronic Disease,
pubmed-meshheading:8080002-Female,
pubmed-meshheading:8080002-Humans,
pubmed-meshheading:8080002-Hyperparathyroidism,
pubmed-meshheading:8080002-Hyperparathyroidism, Secondary,
pubmed-meshheading:8080002-Kidney Failure, Chronic,
pubmed-meshheading:8080002-Male,
pubmed-meshheading:8080002-Middle Aged,
pubmed-meshheading:8080002-Osteocalcin,
pubmed-meshheading:8080002-Parathyroid Hormone,
pubmed-meshheading:8080002-Parathyroidectomy,
pubmed-meshheading:8080002-Peptide Fragments,
pubmed-meshheading:8080002-Postoperative Care,
pubmed-meshheading:8080002-Preoperative Care,
pubmed-meshheading:8080002-Procollagen,
pubmed-meshheading:8080002-Severity of Illness Index
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Procollagen type 1 C-terminal extension peptide serum levels following parathyroidectomy in hyperparathyroid patients.
|
| pubmed:affiliation |
Chair of Nephrology, 3rd Surgical Clinic, La Sapienza University, Rome, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|