Linked Life Data

8078107

Source:http://linkedlifedata.com/resource/pubmed/id/8078107

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-10-3
pubmed:abstractText
The presence of macrophages in the developing or lesioned central nervous system (CNS) led us to study the influence of these cells on neuronal growth. Macrophages were isolated from embryonic rat brain and we observed that factors released in vitro by these cells stimulate neurite growth and regeneration of cultured CNS neurons. This effect was inhibited by antibodies directed against thrombospondin, an extracellular matrix protein that we found to be synthesized and released by brain macrophages. Immunodetection of thrombospondin in the adult rat brain lesioned by kainic acid confirmed the production of this protein by brain macrophages and indicated an early intraparenchymal accumulation of thrombospondin following injury. These results suggest that brain macrophages contribute actively to neurite growth or regeneration during the development or in pathological contexts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0360-4012
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-33
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin.
pubmed:affiliation
INSERM U114, Collège de France, Paris.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't