Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-10-5
|
| pubmed:abstractText |
In the present communication, we describe acrylamide (ACR) induced immunotoxicity and its modulation by an interferon inducer, the 6th mycelial fraction acetone (6-MFA) of Aspergillus ochraceus ATCC 28706. ACR administration to rats produced a significant decrease in the weight of spleen (p < 0.001), thymus (p < 0.001) and mesenteric lymph nodes (p < 0.05). A decrease in cellularity of spleen (p < 0.001), thymus (p < 0.001), bone marrow (p < 0.001) and circulating blood lymphocyte population (p < 0.001) was also recorded. ACR suppressed the humoral as well as cell mediated immunity as assessed by erythrocyte antibody complement (EAC)-rosettes (p < 0.001), hemagglutination titre (p < 0.001), PFC (p < 0.001) and the delayed type hypersensitivity response against sheep red blood cells (SRBC, p < 0.001). ACR treated immunosuppressed rats when treated with 6-MFA restored the circulating lymphocyte number to the normal level and a partial recovery in the weight of spleen and thymus. Potentiation of EAC-rosettes, hemagglutination titre, IgM-PFC and DTH response against SRBC was observed. It is concluded that 6-MFA ameliorate the ACR induced toxicity. This study may be of significance in prevention of ACR toxicity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamide,
http://linkedlifedata.com/resource/pubmed/chemical/Acrylamides,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Inducers,
http://linkedlifedata.com/resource/pubmed/chemical/MFA 6 extract, Aspergillus ochraceus
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0892-3973
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
247-60
|
| pubmed:dateRevised |
2009-5-14
|
| pubmed:meshHeading |
pubmed-meshheading:8077609-Acrylamide,
pubmed-meshheading:8077609-Acrylamides,
pubmed-meshheading:8077609-Animals,
pubmed-meshheading:8077609-Erythrocytes,
pubmed-meshheading:8077609-Fungal Proteins,
pubmed-meshheading:8077609-Hemagglutination,
pubmed-meshheading:8077609-Hemolytic Plaque Technique,
pubmed-meshheading:8077609-Hypersensitivity, Delayed,
pubmed-meshheading:8077609-Immunity,
pubmed-meshheading:8077609-Interferon Inducers,
pubmed-meshheading:8077609-Leukocyte Count,
pubmed-meshheading:8077609-Lymphoid Tissue,
pubmed-meshheading:8077609-Macrophages,
pubmed-meshheading:8077609-Male,
pubmed-meshheading:8077609-Organ Size,
pubmed-meshheading:8077609-Phagocytosis,
pubmed-meshheading:8077609-Rats,
pubmed-meshheading:8077609-Rosette Formation,
pubmed-meshheading:8077609-Sheep
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Acrylamide induced immunosuppression in rats and its modulation by 6-MFA, an interferon inducer.
|
| pubmed:affiliation |
Preventive Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|