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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-9-29
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pubmed:abstractText |
HES-3 is a cerebellar Purkinje cell-specific helix-loop-helix factor structurally related to the products of the Drosophila hairy and Enhancer of split genes. Here, we report the nucleotide sequence and chromosomal locus of the mouse Hes-3 gene. This gene consists of four exons and the exon-intron boundaries are well conserved when compared with those of the mouse Hes-1 and Drosophila hairy genes. Southern blot and interspecies backcross analyses show that the mouse Hes-3 gene is a single-copy gene and is located around position 80 on chromosome 4. Further analysis indicates that this locus is close to the Hes-5 locus, which is different from the Hes-1 locus (position 26 on chromosome 16). These results suggest that the Hes-3 and Hes-5 genes may be clustered on chromosome 4 while the Hes-1 gene is not.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
203
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pubmed:geneSymbol |
Hes-3,
Hes-5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
594-601
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8074710-Amino Acid Sequence,
pubmed-meshheading:8074710-Animals,
pubmed-meshheading:8074710-Base Sequence,
pubmed-meshheading:8074710-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:8074710-Chromosome Mapping,
pubmed-meshheading:8074710-Crosses, Genetic,
pubmed-meshheading:8074710-DNA,
pubmed-meshheading:8074710-DNA-Binding Proteins,
pubmed-meshheading:8074710-Drosophila,
pubmed-meshheading:8074710-Female,
pubmed-meshheading:8074710-Genotype,
pubmed-meshheading:8074710-Helix-Loop-Helix Motifs,
pubmed-meshheading:8074710-Introns,
pubmed-meshheading:8074710-Liver,
pubmed-meshheading:8074710-Male,
pubmed-meshheading:8074710-Mice,
pubmed-meshheading:8074710-Mice, Inbred NOD,
pubmed-meshheading:8074710-Mice, Inbred Strains,
pubmed-meshheading:8074710-Molecular Sequence Data,
pubmed-meshheading:8074710-Purkinje Cells,
pubmed-meshheading:8074710-Restriction Mapping,
pubmed-meshheading:8074710-Sequence Homology, Amino Acid,
pubmed-meshheading:8074710-Sequence Homology, Nucleic Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3.
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pubmed:affiliation |
Institute for Immunology, Kyoto University Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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