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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-9-29
|
| pubmed:abstractText |
Currently available methods to assess reflux of duodenal contents into the esophagus are cumbersome, unphysiologic, and inaccurate. The role of intestino-esophageal reflux has therefore been controversial. We assessed intestino-esophageal reflux using a new system which allows prolonged intraesophageal measurement of bilirubin, the major pigment of bile. Measurements were made with a newly developed fiber-optic sensor electrode connected to a portable data processing unit (BILITEC 2000, Synectics Medical Inc., Sweden). Light absorption was measured at the absorption peak of bilirubin and a reference point. Studies were performed in 9 subjects without esophagitis, 9 subjects with esophagitis and primary reflux disease and 7 subjects with erosive esophagitis after a total or subtotal gastrectomy. The fiberoptic electrode was placed 5 cm above the lower esophageal sphincter. In vitro studies showed linear correlations between absorbance measurements obtained with the BILITEC-unit and known bilirubin and bile acid concentrations, respectively (p < 0.01). Compared to both other groups, light absorption was markedly increased in the subjects who had esophagitis after a total or subtotal gastrectomy (p < 0.05) indicating severe biliary reflux. An increase in bilirubin absorption occurred particularly during the post-prandial and supine periodes (p < 0.01). A Roux-en-Y biliary diversion procedure completely abolished bile reflux in 2 of these patients. These data indicate that ambulatory 24-hour fiberoptic measurement of bilirubin in the esophagus is feasible and allows quantitation of intestino-esophageal reflux. Intestino-esophageal reflux occurs particularly during the postprandial period and the early morning hours in patients who had a previous subtotal or total gastrectomy.
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0044-2771
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
247-51
|
| pubmed:dateRevised |
2009-11-11
|
| pubmed:meshHeading |
pubmed-meshheading:8073796-Adult,
pubmed-meshheading:8073796-Aged,
pubmed-meshheading:8073796-Anastomosis, Roux-en-Y,
pubmed-meshheading:8073796-Bile Acids and Salts,
pubmed-meshheading:8073796-Bile Reflux,
pubmed-meshheading:8073796-Bilirubin,
pubmed-meshheading:8073796-Catheters, Indwelling,
pubmed-meshheading:8073796-Esophagitis, Peptic,
pubmed-meshheading:8073796-Female,
pubmed-meshheading:8073796-Fiber Optic Technology,
pubmed-meshheading:8073796-Follow-Up Studies,
pubmed-meshheading:8073796-Humans,
pubmed-meshheading:8073796-Male,
pubmed-meshheading:8073796-Middle Aged,
pubmed-meshheading:8073796-Monitoring, Physiologic,
pubmed-meshheading:8073796-Optical Fibers,
pubmed-meshheading:8073796-Postgastrectomy Syndromes,
pubmed-meshheading:8073796-Spectrophotometry
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
[Quantifying intestino-esophageal reflux with a fiberoptic bilirubin detection probe].
|
| pubmed:affiliation |
Chirurgische Klinik und Poliklinik, Technische Universität München.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|