Linked Life Data

8067786

Source:http://linkedlifedata.com/resource/pubmed/id/8067786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-9-20
pubmed:abstractText
The comparative effect and safety of 2 IU compared with 4 IU/m2/day of recombinant human growth hormone (rhGH) was studied in 38 growth hormone deficient children regarding the impact of several factors on short term (one year) and long term (three year) growth response. In 21 newly diagnosed patients, three years of rhGH treatment resulted in a significant increase of height velocity SD score, height SD score, and predicted adult height SD score, irrespective of rhGH dose. In 17 transfer patients (previously treated with 12 IU rhGH/m2/week) 4 IU/m2/day resulted in a significantly higher height velocity SD score and height SD score for chronological age than 2 IU/m2/day, while more of them reached their target range or showed a substantial height SD score increment. Height SD score for bone age and predicted adult height SD score only increased significantly with 4 IU rhGH. After one year of rhGH treatment, new patients showed significant negative correlation between delta height SD score with age and baseline insulin-like growth factor I (IGF-I) SD score, and positive correlation with rhGH dose. After three years of treatment, delta height SD score for chronological age was significantly, negatively correlated with age and baseline 'corrected' height SD score (height SD score for chronological age minus target height SD score). There was no significant correlation with rhGH dose. Prolonged treatment with either dose had no adverse effect on IGF-I concentrations, carbohydrate or lipid metabolism. As early age and divergence between height SD score and target height SD score seem more important for growth response than rhGH dose, it is recommended that treatment starts early with 2 IU rhGH/m(2)/day and the dose is doubled if growth is insufficient after several years of treatment.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-1444528, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-1548357, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-2260450, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-229995, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-3324638, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-3513479, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-4311615, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-4342932, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-514086, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6345147, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6637329, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6639123, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6681687, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6694556, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6804746, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6987267, http://linkedlifedata.com/resource/pubmed/commentcorrection/8067786-6994629
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1468-2044
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Comparative effect of two doses of growth hormone for growth hormone deficiency. The Dutch Growth Hormone Working Group.
pubmed:affiliation
Department of Paediatrics, Erasmus University, Rotterdam, The Netherlands.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't