Linked Life Data

8067695

Source:http://linkedlifedata.com/resource/pubmed/id/8067695

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3B
pubmed:dateCreated
1994-9-22
pubmed:abstractText
Childhood acute nonlymphoblastic leukemias (ANLL) of untreated patients were analysed for expression of thymidylate synthase (TS) using immunocytochemistry. Only patients who achieved a complete remission were entered into the study (n = 21 patients). Of the 21 ANLL, 11 showed an overexpression of TS. There exists a strong correlation between the expression of TS and the relapse rate (p = 0.029, Fisher's exact test). Only 3 out of 11 cases of TS-negative patients with ANLL relapsed whereas 8 out of 10 TS-positive cases experienced relapses. The relapse-free intervals of the patients with TS-positive leukemic cells were significantly shorter than those of patients with TS-negative leukemic cells (p = 0.025, log rank test). There was a trend for shorter overall survival times of patients with TS-positive leukemic cells compared with patients with TS-negative leukemic cells (p = 0.12).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1271-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Thymidylate synthase in childhood acute non-lymphoblastic leukemia.
pubmed:affiliation
German Cancer Research Center, Heidelberg.
pubmed:publicationType
Journal Article