| pubmed-article:8065913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:8065913 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:8065913 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:8065913 | pubmed:dateCreated | 1994-9-21 | lld:pubmed |
| pubmed-article:8065913 | pubmed:abstractText | The human excision repair gene ERCC-1 gene restores normal resistance to UV and mitomycin C in excision repair deficient chinese hamster ovary cells of complementation group 1. To investigate the involvement of the ERCC-1 gene in gene-specific repair of bulky lesions, we have studied the removal of damage induced by the antitumor agent cisplatin in CHO mutant 43-3B cells of group 1, with or without transfection with the ERCC-1 gene. Firstly, we determined the contribution of the ERCC-1 gene to the repair of interstrand crosslinks (ICL) induced by cisplatin and found efficient removal of ICLs from the dihydrofolate reductase (DHFR) gene in the ERCC-1 transfected 43-3B cells. We then assessed the contribution of ERCC-1 to the repair of intrastrand adducts (IA) induced by cisplatin. Compared to the wild-type parental cell line, the ERCC-1 transfected 43-3B cells repaired the IAs in the DHFR gene inefficiently. Thus, our data suggest that the ERCC-1 gene is more involved in the repair of interstrand crosslinks than in the removal of intrastrand adducts. | lld:pubmed |
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| pubmed-article:8065913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8065913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8065913 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8065913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8065913 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8065913 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:8065913 | pubmed:author | pubmed-author:BohrV AVA | lld:pubmed |
| pubmed-article:8065913 | pubmed:author | pubmed-author:LarminatFF | lld:pubmed |
| pubmed-article:8065913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8065913 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:8065913 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:8065913 | pubmed:geneSymbol | ERCC-1 | lld:pubmed |
| pubmed-article:8065913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8065913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8065913 | pubmed:pagination | 3005-10 | lld:pubmed |
| pubmed-article:8065913 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8065913 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8065913 | pubmed:articleTitle | Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage. | lld:pubmed |
| pubmed-article:8065913 | pubmed:affiliation | Laboratory of Molecular Genetics, National Institute on Aging, NIH, Baltimore, MD 21224. | lld:pubmed |
| pubmed-article:8065913 | pubmed:publicationType | Journal Article | lld:pubmed |
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