Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1994-9-21
pubmed:abstractText
The human excision repair gene ERCC-1 gene restores normal resistance to UV and mitomycin C in excision repair deficient chinese hamster ovary cells of complementation group 1. To investigate the involvement of the ERCC-1 gene in gene-specific repair of bulky lesions, we have studied the removal of damage induced by the antitumor agent cisplatin in CHO mutant 43-3B cells of group 1, with or without transfection with the ERCC-1 gene. Firstly, we determined the contribution of the ERCC-1 gene to the repair of interstrand crosslinks (ICL) induced by cisplatin and found efficient removal of ICLs from the dihydrofolate reductase (DHFR) gene in the ERCC-1 transfected 43-3B cells. We then assessed the contribution of ERCC-1 to the repair of intrastrand adducts (IA) induced by cisplatin. Compared to the wild-type parental cell line, the ERCC-1 transfected 43-3B cells repaired the IAs in the DHFR gene inefficiently. Thus, our data suggest that the ERCC-1 gene is more involved in the repair of interstrand crosslinks than in the removal of intrastrand adducts.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1380646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1433335, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1438274, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1475197, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1551896, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-1945841, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2016318, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2181258, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2420469, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2499774, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2836856, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2918869, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-2991268, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3021728, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3023360, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3344216, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3412890, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3621344, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-3897194, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-4039603, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-6462228, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-6889678, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-7360150, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8253090, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8253091, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8324733, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8337762, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8398280, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8465201, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8479526, http://linkedlifedata.com/resource/pubmed/commentcorrection/8065913-8517854
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
22
pubmed:geneSymbol
ERCC-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3005-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Role of the human ERCC-1 gene in gene-specific repair of cisplatin-induced DNA damage.
pubmed:affiliation
Laboratory of Molecular Genetics, National Institute on Aging, NIH, Baltimore, MD 21224.
pubmed:publicationType
Journal Article