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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
33
|
| pubmed:dateCreated |
1994-9-21
|
| pubmed:abstractText |
The nucleic acid analogues PNA (peptide nucleic acids) hybridize with DNA of complementary sequence. The solution structures of two PNA-DNA duplexes, H-(GCTATGTC)-NH2.d(GACATAGC) and H-(GTAGATCACT)-NH2.d(AGTGATCTAC), have been studied by 1H NMR. It was found that the PNA-DNA hybrids are base paired by hydrogen bonds, most likely of the Watson-Crick type. From two-dimensional NOESY and COSY results it is concluded that the DNA strand in the PNA-DNA complex adopts a B-like structure with the deoxyribose sugars in the C2'-endo conformation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-2960
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
33
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
9820-5
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8060989-Base Composition,
pubmed-meshheading:8060989-Base Sequence,
pubmed-meshheading:8060989-DNA,
pubmed-meshheading:8060989-Hydrogen Bonding,
pubmed-meshheading:8060989-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8060989-Molecular Sequence Data,
pubmed-meshheading:8060989-Nucleic Acid Conformation,
pubmed-meshheading:8060989-Nucleic Acid Hybridization,
pubmed-meshheading:8060989-Nucleic Acids,
pubmed-meshheading:8060989-Protons
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Structural characterization of PNA-DNA duplexes by NMR. Evidence for DNA in a B-like conformation.
|
| pubmed:affiliation |
Department of Biophysics, Arrhenius Laboratory, Stockholm University, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|