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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6 Suppl 1
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pubmed:dateCreated |
1975-9-4
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pubmed:abstractText |
Prostaglandins are primarily local or tissue hormones which have their effects at or near the site of release and are metabolized before reaching the arterial circulation. A possible exception is prostaglandin A-2, which has been proposed as a circulating hormone; however, there is no evidence that prostaglandin A-2 is biosynthesized in the mammalian kidney or even in extrarenal tissues. The prostaglandin generated and released in the kidney is predominantly E-2. Some blood vessels also synthesize prostaglandins intramurally, where their local release influences vascular tone and reactivity. Endogenous prostaglandin E-2 production contributes to the regulation of blood pressure by (1) opposing the vasoconstrictor and antidiuretic actions of circulating pressor hormones; (2) braking the release of norepinephrine from vasoconstrictor nerves; and (3) participating in the control extracellular fluid volume through its renal hemodynamic actions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0009-7330
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:805673-Angiotensin II,
pubmed-meshheading:805673-Animals,
pubmed-meshheading:805673-Blood Pressure,
pubmed-meshheading:805673-Bradykinin,
pubmed-meshheading:805673-Cyclooxygenase Inhibitors,
pubmed-meshheading:805673-Homeostasis,
pubmed-meshheading:805673-Hyperemia,
pubmed-meshheading:805673-Hypertension,
pubmed-meshheading:805673-Indomethacin,
pubmed-meshheading:805673-Kidney,
pubmed-meshheading:805673-Norepinephrine,
pubmed-meshheading:805673-Prostaglandins,
pubmed-meshheading:805673-Prostaglandins A,
pubmed-meshheading:805673-Prostaglandins F,
pubmed-meshheading:805673-Radioimmunoassay,
pubmed-meshheading:805673-Regional Blood Flow,
pubmed-meshheading:805673-Renin,
pubmed-meshheading:805673-Sympathetic Nervous System,
pubmed-meshheading:805673-Water-Electrolyte Balance,
pubmed-meshheading:805673-Wounds and Injuries
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pubmed:year |
1975
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pubmed:articleTitle |
Possible contributions of endogenous prostaglandins to the control of blood pressure.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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