Linked Life Data

8054515

Source:http://linkedlifedata.com/resource/pubmed/id/8054515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-9-12
pubmed:abstractText
Renal cell cancer is a common malignancy with a poor response to multiple therapeutic modalities. Immunotherapy is the most promising of the various treatment approaches tried. Recently, Interleukin-2 has been approved by the Food and Drug Administration for the treatment of metastatic kidney cancer. However, the relatively low response rate (15-30%) and the limiting toxicity of immunotherapy regimens stress the need to develop new therapeutic modalities. Experimental animal models are instrumental in the development of new treatment alternatives. We describe several of the animal models available for the study of kidney cancer and discuss on-going preclinical investigations in the murine renal adenocarcinoma system (Renca), the Wistar-Lewis rat model, and human renal cancer xenograft models in immunodeficient mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0258-851X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-80
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Experimental animal models for the study of therapeutic approaches in renal cell carcinoma.
pubmed:affiliation
Department of Urology, Wayne State University School of Medicine, Detroit, MI 48201.
pubmed:publicationType
Journal Article, Review