Linked Life Data

805079

Source:http://linkedlifedata.com/resource/pubmed/id/805079

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
1975-8-4
pubmed:abstractText
In previous communications we have reported using the rat fed by total parenteral nutrition to examine the effects of the absence of food from the gut on functional and structural parameters of the gastrointestinal tract. In the current study three groups of animals were fed parenterally; one received a continuous infusion of pentagastrin equal to about one-half the D50 for acid secretion, another received a comparable infusion of histamine, and a third group was given only the liquid diet. These animals were compared to orally fed sham operated controls. The parenterally fed animals had significantly lower levels of antral and serum gastrin. When compared to whole body weight, the weights of the oxyntic gland area of the stomach, the pancreas, and the small intestine were significantly lower. In addition, the total and specific activities of the disaccharidase enzymes were significantly reduced. Pentagastrin prevented both the decreases in weights of the gastrointestinal tissues and the decreases in dissaccharidase activity. Histamine was without effect. We conclude that pentagastrin prevents the changes in gastrointestinal structure and function caused by the absence of food from the gut and that the trophic action of gastrin is necessary for the maintenance of the functional and structural integrity of the gastrointestinal tract.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1184-92
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Action of gastrin on gastrointestinal structure and function.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.