Linked Life Data

8047720

Source:http://linkedlifedata.com/resource/pubmed/id/8047720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-8-26
pubmed:abstractText
The distribution of epidermal growth factor (EGF) and EGF receptor (EGFR) in adult human lung was examined by immunohistochemistry and immunoelectron microscopy. EGF immunoreactivity was observed in secretory granules and endoplasmic reticulum of serous acinar cells of bronchial glands. EGFR immunoreactivity was detected at the cell membrane of the basal cells and the bronchial surface nonciliated cells (indifferent cells) in the bronchus, the nonciliated bronchiolar cells (Clara cells) and the type II pneumocytes in peripheral lung. These results suggest that EGF is secreted into bronchial surface fluid from the bronchial glands and stimulates proliferation and/or differentiation of basal cells and indifferent cells of the bronchus, although the source of EGF responsive to Clara cells and the type II pneumocytes of peripheral lung was not determined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7931
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-6
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Distribution of epidermal growth factor and epidermal growth factor receptor in human lung: immunohistochemical and immunoelectron-microscopic studies.
pubmed:affiliation
Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan.
pubmed:publicationType
Journal Article