| pubmed-article:804475 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0001407 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0009226 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0030016 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:804475 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:804475 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:804475 | pubmed:dateCreated | 1975-7-2 | lld:pubmed |
| pubmed-article:804475 | pubmed:abstractText | Microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase prepared from either rat liver or human fibroblasts was shown to be inactivated in vitro by a factor in extracts of cultured human fibroblasts in a reaction requiring ATP or ADP and Mg2+ or Mn2+. The inactivation factor was found in the soluble fraction of fibroblasts extracts and was shown to be heat-labile, nondialyzable, and precipitable with ammonium sulfate. The inactivation reaction was prevented by the addition of either an ATP-regenerating system or an ADP-regenerating system, suggesting that the presence of both adenine nucleotides may be required. A series of kinetic experiments suggested that the fibroblast inactivation factor catalyzes the conversion of the microsomal enzyme from an active to an inactive form. The finding that solubilized preparations of 3-hydroxy-3-methylglutaryl coenzyme A reductase from both rat liver and human fibroblasts were resistant to inactivation raises the possibility that some unidentified microsomal component also may participate in the inactivation reaction. | lld:pubmed |
| pubmed-article:804475 | pubmed:language | eng | lld:pubmed |
| pubmed-article:804475 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:804475 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:804475 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:804475 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:804475 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:804475 | pubmed:author | pubmed-author:BrownM SMS | lld:pubmed |
| pubmed-article:804475 | pubmed:author | pubmed-author:GoldsteinJ... | lld:pubmed |
| pubmed-article:804475 | pubmed:author | pubmed-author:BrunschedeG... | lld:pubmed |
| pubmed-article:804475 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:804475 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:804475 | pubmed:volume | 250 | lld:pubmed |
| pubmed-article:804475 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:804475 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:804475 | pubmed:pagination | 2502-9 | lld:pubmed |
| pubmed-article:804475 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:804475 | pubmed:year | 1975 | lld:pubmed |
| pubmed-article:804475 | pubmed:articleTitle | Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts. | lld:pubmed |
| pubmed-article:804475 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:804475 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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