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pubmed-article:8044687pubmed:abstractTextBinding of a peripheral benzodiazepine receptor ligand was used to quantify the reactive gliosis resulting from neuronal damage induced by systemic injections of kainic acid 7 days previously. The enhancement of binding in rat hippocampus could be prevented by injections of the purine analogue (R)-N6-phenylisopropyladenosine at 25 microgram/kg up to 2 h before or after the toxin. These results indicate that the purine is able to prevent neurotoxicity by interrupting events occurring some time after kainate administration.lld:pubmed
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pubmed-article:8044687pubmed:articleTitleTime course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding.lld:pubmed
pubmed-article:8044687pubmed:affiliationDepartment of Pharmacology, University of Glasgow, Scotland.lld:pubmed
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