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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-30
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pubmed:abstractText |
Binding of a peripheral benzodiazepine receptor ligand was used to quantify the reactive gliosis resulting from neuronal damage induced by systemic injections of kainic acid 7 days previously. The enhancement of binding in rat hippocampus could be prevented by injections of the purine analogue (R)-N6-phenylisopropyladenosine at 25 microgram/kg up to 2 h before or after the toxin. These results indicate that the purine is able to prevent neurotoxicity by interrupting events occurring some time after kainate administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0361-9230
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
133-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8044687-Animals,
pubmed-meshheading:8044687-Hippocampus,
pubmed-meshheading:8044687-Isoquinolines,
pubmed-meshheading:8044687-Kainic Acid,
pubmed-meshheading:8044687-Male,
pubmed-meshheading:8044687-Phenylisopropyladenosine,
pubmed-meshheading:8044687-Radioligand Assay,
pubmed-meshheading:8044687-Rats,
pubmed-meshheading:8044687-Rats, Wistar,
pubmed-meshheading:8044687-Time Factors,
pubmed-meshheading:8044687-Tritium
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pubmed:year |
1994
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pubmed:articleTitle |
Time course of purine protection against kainate-induced increase in hippocampal [3H]-PK11195 binding.
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pubmed:affiliation |
Department of Pharmacology, University of Glasgow, Scotland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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