Linked Life Data

8044591

Source:http://linkedlifedata.com/resource/pubmed/id/8044591

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-9-1
pubmed:abstractText
An organ culture of human saphenous vein was used as a model of vein graft intimal hyperplasia and the potential of Losartan, an angiotensin II receptor antagonist, to inhibit neointimal proliferation was investigated. Median (range) neointimal thickness was reduced from 17 (16-19) to 11 (8-18) microns in veins cultured with Losartan (median difference 5 (95 per cent confidence interval 2-8) microns). A similar decrease in the median neointimal proliferation index was seen from 21 (range 14-47) to 15 (range 5-31) per cent (median difference 8 per cent (95 per cent confidence interval 5-11 per cent)). These results demonstrate that angiotensin II receptor antagonists may be of therapeutic value for the modulation of vein graft intimal hyperplasia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1323
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
819-22
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Influence of Losartan, an angiotensin receptor antagonist, on neointimal proliferation in cultured human saphenous vein.
pubmed:affiliation
Department of Surgery, University of Leicester, UK.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't