Linked Life Data

8041631

Source:http://linkedlifedata.com/resource/pubmed/id/8041631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1994-8-24
pubmed:abstractText
Interleukin-1 beta (Il-1 beta), a key cytokine in the acute phase response, elevates hepatic expression of both the heavy (H) and light (L) ferritin subunits without influencing the steady-state levels of either ferritin transcript. Transfection experiments with human hepatoma cells reveal that sequences within the 5' untranslated region (5'UTR) of H-ferritin mRNA confer translational regulation to chimaeric chloramphenicol acetyl transferase (CAT) mRNAs in response to Il-1 beta in the absence of marked changes in CAT mRNA levels. Il-1 beta dependent translational enhancement is mediated by a distinct G + C rich RNA sequence within 70 nucleotides (nt) of the start codon. The upstream Iron Responsive Element RNA stemloop does not confer increased expression to CAT mRNA in Il-1 beta stimulated hepatoma transfectants. A 38 nucleotide consensus sequence within the 5'UTRs of the mRNAs encoding the hepatic acute phase proteins alpha 1-antitrypsin (alpha 1AT), alpha 1-acid glycoprotein (AGP) and haptoglobin (Dente et al., 1985) is similar to sequences in the G + C rich H-ferritin mRNA translational regulatory element. Deletion of three nucleotides from this region of the 61 nt G + C rich element in the H-ferritin mRNA 5' leader eliminates Il-1 beta translational enhancement of the CAT reporter transcripts.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1502165, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1531143, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1696948, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1701143, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1903535, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-1909029, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2052577, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2199284, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2247055, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2409529, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2457587, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2470368, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2482418, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2555173, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2601712, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2752428, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2822385, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2985281, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2991275, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-2994062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3003694, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3127826, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3200835, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3288540, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3304136, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3410854, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3413484, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3461723, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3470792, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3478702, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3479802, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3685996, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3840373, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3858810, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-3943125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-4705382, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-518835, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-588480, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6083565, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6091052, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6248960, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6326753, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6409417, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6421877, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6546423, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-659425, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-6960240, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-7046585, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-7295586, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-8380757, http://linkedlifedata.com/resource/pubmed/commentcorrection/8041631-8464737
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2678-86
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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