| pubmed-article:8041116 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0018284 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:8041116 | lifeskim:mentions | umls-concept:C0064719 | lld:lifeskim |
| pubmed-article:8041116 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8041116 | pubmed:dateCreated | 1994-8-19 | lld:pubmed |
| pubmed-article:8041116 | pubmed:abstractText | A single intravenous injection of lead nitrate to rats induces a synchronized wave of hepatocyte proliferation without accompanying liver cell necrosis. However, the mechanism of the mitogenic effect of lead nitrate is not known, and whether hepatocyte growth factor (HGF), transforming growth factor-alpha (TGF-alpha), and transforming growth factor-beta 1 (TGF-beta 1) play any role in it have not been investigated. These growth factors have indeed been shown to provide either positive or negative stimuli for liver cell regeneration after partial hepatectomy or liver cell necrosis. Moreover, there are reports showing that administration of non-necrogenic doses of tumor necrosis factor-alpha (TNF-alpha) to rats lead to an enhanced proliferation of hepatocytes and liver nonparenchymal cells. Lead is known to sensitize animals to lethal effects of bacterial lipopolysaccharides (LPS), suggesting that lead nitrate may modify the production of TNF-alpha in response to endogenous LPS of intestinal origin. An enhanced production of TNF-alpha could therefore be involved in the mitogenic action of lead nitrate. | lld:pubmed |
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| pubmed-article:8041116 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8041116 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8041116 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8041116 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8041116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8041116 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8041116 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8041116 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8041116 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:NakamuraTT | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:ShinozukaHH | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:KatyalS LSL | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:KuboYY | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:ColumbanoAA | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:ConeTT | lld:pubmed |
| pubmed-article:8041116 | pubmed:author | pubmed-author:Ledda-Columba... | lld:pubmed |
| pubmed-article:8041116 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8041116 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:8041116 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8041116 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8041116 | pubmed:pagination | 35-41 | lld:pubmed |
| pubmed-article:8041116 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8041116 | pubmed:meshHeading | pubmed-meshheading:8041116-... | lld:pubmed |
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| pubmed-article:8041116 | pubmed:meshHeading | pubmed-meshheading:8041116-... | lld:pubmed |
| pubmed-article:8041116 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8041116 | pubmed:articleTitle | Roles of growth factors and of tumor necrosis factor-alpha on liver cell proliferation induced in rats by lead nitrate. | lld:pubmed |
| pubmed-article:8041116 | pubmed:affiliation | Department of Pathology, University of Pittsburgh School of Medicine, Pennsylvania. | lld:pubmed |
| pubmed-article:8041116 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8041116 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8041116 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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