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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-8-25
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pubmed:abstractText |
Apolipoprotein E (apo E)-deficient mice are severely hypercholesterolemic and develop advanced atheromas independent of diet. The C57BL/6 strain differs from most inbred strains by having lower HDL concentrations and a high risk of developing early atherosclerotic lesions when fed an atherogenic diet. The relative HDL deficiency and atherosclerosis susceptibility of the C57BL/6 strain are corrected with the expression of a human apolipoprotein AI (apo AI) transgene in this genetic background. To examine if increases in apo AI and HDL are also effective in minimizing apo E deficiency--induced atherosclerosis, we introduced the human apo AI transgene into the hypercholesterolemic apo E knockout background. Similar elevations of total plasma cholesterol occurred in both the apo E knockout and apo E knockout mice also expressing the human apo AI transgene. The latter animals, however, also showed a two- to threefold increase in HDL and a sixfold decrease in susceptibility to atherosclerosis. This study demonstrates that elevating the concentration of apo AI reduces atherosclerosis in apo E deficient-mice and suggests that elevation of apo AI and HDL may prove to be a useful approach for treating unrelated causes of heightened atherosclerosis susceptibility.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1301210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1411543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1423598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1465128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-15403115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1584779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1591233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1703299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1907375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-1910153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-2495286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-2499515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-2706836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3283935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3473481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3511384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3544775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3606719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3724517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-3841001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-4818200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-8316302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-8332912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8040345-8413656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
899-903
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8040345-Animals,
pubmed-meshheading:8040345-Apolipoprotein A-I,
pubmed-meshheading:8040345-Apolipoprotein E4,
pubmed-meshheading:8040345-Apolipoproteins E,
pubmed-meshheading:8040345-Arteriosclerosis,
pubmed-meshheading:8040345-Female,
pubmed-meshheading:8040345-Genotype,
pubmed-meshheading:8040345-Humans,
pubmed-meshheading:8040345-Lipoproteins, HDL,
pubmed-meshheading:8040345-Male,
pubmed-meshheading:8040345-Mice,
pubmed-meshheading:8040345-Mice, Inbred C57BL,
pubmed-meshheading:8040345-Mice, Transgenic
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pubmed:year |
1994
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pubmed:articleTitle |
Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice.
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pubmed:affiliation |
Life Sciences Division, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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