Linked Life Data

8039798

Source:http://linkedlifedata.com/resource/pubmed/id/8039798

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-8-19
pubmed:abstractText
The HLA-DQ alpha genotype and allele frequencies in 130 Malays, 125 Chinese, and 137 Indians in the Malaysian population were determined using a commercial HLA-DQ alpha DNA amplification and typing kit which distinguishes 6 alleles (DQA1.1, DQA1.2, DQA1.3, DQA2, DQA3, and DQA4) and 21 possible genotypes at this locus. All 21 genotypes were encountered in the Malay and Indian samples, but DQA1.1,DQA1.3 and DQA2,DQA2 genotypes were absent in the Chinese sample. In all three ethnic groups, the numbers observed for the various DQ alpha genotypes were in accordance with those expected from Hardy-Weinberg equilibrium. The allele frequencies observed in these three groups were significantly different to allow them to be distinguished as distinct populations. For the Malays, Chinese, and Indians, heterozygosity values at this locus were 0.77, 0.77, and 0.83, respectively, and values of the power of discrimination were 0.91, 0.90, and 0.94, respectively. These population data will enable the HLA-DQ alpha locus to be used as a marker in forensic identity testing in Malaysia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-5652
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
150-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
HLA-DQ alpha genotype and allele frequencies in Malays, Chinese, and Indians in the Malaysian population.
pubmed:affiliation
Department of Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't