Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-24
pubmed:abstractText
Basal forebrain (BF) injections of ibotenic (IBO) acid impair memory, whereas quisqualic (QUIS) acid injections do not. The authors investigated whether the cytotoxicity and differential behavioral effects of IBO and QUIS in rats depend on the generation of nitric oxide (NO). Injections of IBO or sodium nitroprusside (NP), but not QUIS, significantly increased BF NO formation, as determined by guanosine 3,5-cyclic monophosphate levels. IBO, alone or coinjected with methylene blue (MB), and QUIS, alone or coinjected with NP, decreased cortical choline acetyltransferase (ChAT) activity and the number of ChAT-positive BF neurons. The BF levels of galanin or neuropeptide Y were unchanged in all lesion groups. QUIS, but not IBO, dose-dependently destroyed NO-producing BF cells. Injections of IBO, with or without MB, impaired choice accuracy in a T-maze alternation task. The results suggest that the generation of NO in the BF does not underlie the spatial working memory deficit produced by IBO.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0735-7044
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8037871-Animals, pubmed-meshheading:8037871-Brain Mapping, pubmed-meshheading:8037871-Cerebral Cortex, pubmed-meshheading:8037871-Choline O-Acetyltransferase, pubmed-meshheading:8037871-Cyclic GMP, pubmed-meshheading:8037871-Discrimination Learning, pubmed-meshheading:8037871-Ibotenic Acid, pubmed-meshheading:8037871-Male, pubmed-meshheading:8037871-Mental Recall, pubmed-meshheading:8037871-Methylene Blue, pubmed-meshheading:8037871-Neurons, pubmed-meshheading:8037871-Neuropeptide Y, pubmed-meshheading:8037871-Nitric Oxide, pubmed-meshheading:8037871-Nitroprusside, pubmed-meshheading:8037871-Orientation, pubmed-meshheading:8037871-Quisqualic Acid, pubmed-meshheading:8037871-Rats, pubmed-meshheading:8037871-Receptors, AMPA, pubmed-meshheading:8037871-Receptors, GABA, pubmed-meshheading:8037871-Retention (Psychology), pubmed-meshheading:8037871-Substantia Innominata
pubmed:year
1994
pubmed:articleTitle
Nitric oxide formation does not underlie the memory deficits produced by ibotenate injections into the nucleus basalis of rats.
pubmed:affiliation
Division of Neural Systems, Memory and Aging, University of Arizona, Tucson 85724.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.