Linked Life Data

8034180

Source:http://linkedlifedata.com/resource/pubmed/id/8034180

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-8-17
pubmed:abstractText
Nine inbred mouse strains surveyed for erythrocytic guanosine-5'-triphosphate (GTP) concentration were found to segregate into two discrete groups. Strains having low GTP levels between 1.4 and 3.4 nmol/10(9) cells were C3H/HeJ, C3H/HeHa, A/J, and WB/ReJ. Strains having high GTP levels between 11.0 and 14.8 nmol/10(9) cells were AKR/J, DBA/2J, CBA/J, C57BL/6J, and C57L/J. Erythrocytic ATP levels did not vary significantly among these groups. Crosses between low and high GTP strains gave F1 progeny having intermediate levels of GTP, and the progeny of F1's backcrossed to parental strains segregated in a 1:1 ratio for GTP concentration. We designated the GTP concentration determining trait, Gtpc. Typing the C57BL/6J x C3H/HeJ (B x H) recombinant inbred strains for GTP levels revealed 0/12 strain distribution pattern differences for loci on both chromosomes 5 and 9. Backcross analysis did not provide evidence for linkage of Gtpc to W (dominant white spotting) on chromosome 5 with 15/45 recombinants. A test for linkage of Gtpc to transferrin (Trf) on chromosome 9 gave evidence of linkage with an observed recombination frequency of 14.6 +/- 5.5 and a 99% confidence interval of 3.9-33.9 cM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0831-2796
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:geneSymbol
Bg1, Emv-1, En-2, Fv-2, Gtpc, Ltw-3, Mpmv-13, Pmv-5, Qdpr, Ras12-2, kfo-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-404
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Assignment of a gene that determines erythrocytic guanosine-5'-triphosphate concentration (Gtpc) to mouse chromosome 9.
pubmed:affiliation
Department of Paediatrics, Faculty of Medicine, University of Calgary, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't