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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-8-8
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pubmed:abstractText |
Bcl-2 functions as a death repressor molecule in an evolutionarily conserved cell death pathway. To further explore the role of Bcl-2 in development, we assessed its pattern of expression during murine embryogenesis. Immunohistochemical analysis demonstrates that Bcl-2 is widely expressed early in mouse fetal development in tissues derived from all three germ layers and that this expression becomes restricted with maturation. Within epithelium, the E12.5 lung bud demonstrates a proximal to distal gradient of Bcl-2 expression which is enhanced by E18.5. Bcl-2 is expressed throughout the intestinal epithelium through E14.5, but by E18.5 only cells in the crypts and lower villi express Bcl-2. In the mesoderm-derived kidney, Bcl-2 is expressed in both the ureteric bud and metanephric cap tissue at E12.5. Tubular structures also express Bcl-2, although overall levels drop as the kidney matures. Retinal neuroepithelial cells uniformly express Bcl-2 until cells begin to differentiate and then display the topographic distribution maintained into adulthood. The developing limb provides a clear example where Bcl-2 is restricted to zones of cell survival; Bcl-2 is expressed in the digital zones but not in the interdigital zones of cell death. The wide distribution of Bcl-2 in the developing mouse suggests that many immature cells require a death repressor molecule or that Bcl-2 may have roles beyond regulating developmental cell death.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1447305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1453000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1470921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1502141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1835668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1871110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1959134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-1987477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2183011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2184193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2201196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2250705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2651903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2834197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-2875799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3153305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3262202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3300794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3346373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3500184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3584558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-3760758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-4069356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-6476402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-6501608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-6663225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-6716044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-7503812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-7678514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-7679361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-7681256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-7682708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8030758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8076517,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8149910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8235659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8313913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8345191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8358789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8360476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8381212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8398150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8030757-8402909
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8030757-Animals,
pubmed-meshheading:8030757-Brain Chemistry,
pubmed-meshheading:8030757-Embryo, Mammalian,
pubmed-meshheading:8030757-Embryonic and Fetal Development,
pubmed-meshheading:8030757-Epithelium,
pubmed-meshheading:8030757-Extremities,
pubmed-meshheading:8030757-Intestine, Small,
pubmed-meshheading:8030757-Kidney,
pubmed-meshheading:8030757-Liver,
pubmed-meshheading:8030757-Lung,
pubmed-meshheading:8030757-Mice,
pubmed-meshheading:8030757-Mice, Inbred C3H,
pubmed-meshheading:8030757-Mice, Inbred C57BL,
pubmed-meshheading:8030757-Proto-Oncogene Proteins,
pubmed-meshheading:8030757-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8030757-Sense Organs
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pubmed:year |
1994
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pubmed:articleTitle |
Bcl-2 protein expression during murine development.
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pubmed:affiliation |
Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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