Linked Life Data

8026559

Source:http://linkedlifedata.com/resource/pubmed/id/8026559

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-8-10
pubmed:abstractText
The effect of L-arginine on isolated human uterine artery rings was investigated. L-Arginine, but not D-arginine, induced concentration-dependent relaxation. Removal of the endothelium enhanced the relaxant effects of L-arginine. Methylene blue and dexamethasone non-competitively inhibited L-arginine-induced relaxation, while NG-monomethyl-L-arginine competitively antagonized the response to L-arginine. Calmidazolium did not affect relaxation evoked by L-arginine. The dissociation constants obtained for L-arginine and NG-monomethyl-L-arginine in intact rings were not significantly different from those in endothelium-denuded rings. It is concluded that the relaxation induced by L-arginine in human uterine artery is mediated by non-endothelial nitric oxide production. We suggest that the NO synthase mediating the L-arginine-induced relaxation is an inducible type.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
256
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
L-arginine induces relaxation of human uterine artery with both intact and denuded endothelium.
pubmed:affiliation
Department of Pharmacology, University Medical Center, Medical Faculty, Belgrade, Yugoslavia.
pubmed:publicationType
Journal Article, In Vitro