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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-8-4
|
| pubmed:abstractText |
A theoretical model is proposed according to which the quasi-parabolic dependence of the biological activity of amphiphilic compounds on their hydrophobic substituent chain length (the "cut-off" effect) is caused by a combination of partition equilibria and geometrical parameters of these compounds interacting with the bilayer of phospholipid membranes. The most important parameter seems to be a change in the thickness of the phospholipid bilayer. The model is quantified for the case of normal alcohols.
|
| pubmed:language |
slo
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1210-7816
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
87-91
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1994
|
| pubmed:articleTitle |
[Surfactant interactions in model and biological membranes. IX. Theoretical model of biological activity in relation to the length of hydrocarbon chains].
|
| pubmed:affiliation |
Katedra fyzikálnej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|