Linked Life Data

8018093

Source:http://linkedlifedata.com/resource/pubmed/id/8018093

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2A
pubmed:dateCreated
1994-7-27
pubmed:abstractText
The 13-week oral toxicity of nefiracetam (N-(2,6-dimethylphenyl)-2-(2-oxo- 1-pyrrolidinyl) acetamide, DM-9384, CAS 77191-36-7), a new cognition-enhancing agent, was investigated in Beagle dogs of both sexes. No change was observed in the 20 mg/kg group. Hypospermatogenesis and slightly increased deposition of hemosiderin in the spleen were seen in male dogs treated with 60 mg/kg or more. Dosing at 180 mg/kg induced a decrease in food consumption, increases in urinary volume and urinary protein, and renal papillary necrosis in both male and female dogs. The non-toxic dose was 20 mg/kg under these experimental conditions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs.
pubmed:affiliation
Drug Safety Research Center, Developmental Research Laboratories, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan.
pubmed:publicationType
Journal Article