| pubmed-article:8012645 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8012645 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8012645 | lifeskim:mentions | umls-concept:C0004057 | lld:lifeskim |
| pubmed-article:8012645 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:8012645 | lifeskim:mentions | umls-concept:C1319853 | lld:lifeskim |
| pubmed-article:8012645 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8012645 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8012645 | pubmed:dateCreated | 1994-7-25 | lld:pubmed |
| pubmed-article:8012645 | pubmed:abstractText | We studied the effect of aspirin on beta-adrenergic receptors in lymphocytes from three groups of subjects: 5 asthmatic patients presenting sensitivity to aspirin, 10 asthmatic patients with tolerance to aspirin and a control group. Lymphocytes were incubated with aspirin-lysine (36 micrograms/ml). The number of beta-receptors/cell and the dissociation constants (Kd) were assessed by means of [125I]-cyanopindolol (ICYP). There was a decrease in the number of beta-receptors after incubation with aspirin in all asthmatic patients with sensitivity. The differences between mean basal (660 +/- 171 receptors/cell) and postincubation (398 +/- 110 receptors/cell) values were significant (p < 0.05). There were also significant differences (p < 0.01) between basal (23.4 +/- 6 pM) and postincubation (15 +/- 5.1 pM) Kd values, which indicates that the affinity of ICYP increased. In the subjects in the other two groups, aspirin both increased and decreased the number of beta-receptors, but the effects were not significant. It is suggested that in patients with sensitivity, aspirin could induce changes in the plasmatic membrane, thus altering beta-receptors or inducing the release of inflammatory mediators that exert their effect upon these receptors. | lld:pubmed |
| pubmed-article:8012645 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8012645 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8012645 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8012645 | pubmed:issn | 1018-9068 | lld:pubmed |
| pubmed-article:8012645 | pubmed:author | pubmed-author:SanzM LML | lld:pubmed |
| pubmed-article:8012645 | pubmed:author | pubmed-author:OehlingAA | lld:pubmed |
| pubmed-article:8012645 | pubmed:author | pubmed-author:CroceMM | lld:pubmed |
| pubmed-article:8012645 | pubmed:author | pubmed-author:CórdobaHH | lld:pubmed |
| pubmed-article:8012645 | pubmed:author | pubmed-author:Costa-MansoEE | lld:pubmed |
| pubmed-article:8012645 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8012645 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:8012645 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8012645 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8012645 | pubmed:pagination | 288-93 | lld:pubmed |
| pubmed-article:8012645 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
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| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
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| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:meshHeading | pubmed-meshheading:8012645-... | lld:pubmed |
| pubmed-article:8012645 | pubmed:articleTitle | Effect of aspirin on beta-receptors in lymphocytes from patients with aspirin-induced asthma. | lld:pubmed |
| pubmed-article:8012645 | pubmed:affiliation | Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain. | lld:pubmed |
| pubmed-article:8012645 | pubmed:publicationType | Journal Article | lld:pubmed |
