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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-7-25
|
| pubmed:abstractText |
We studied the effect of aspirin on beta-adrenergic receptors in lymphocytes from three groups of subjects: 5 asthmatic patients presenting sensitivity to aspirin, 10 asthmatic patients with tolerance to aspirin and a control group. Lymphocytes were incubated with aspirin-lysine (36 micrograms/ml). The number of beta-receptors/cell and the dissociation constants (Kd) were assessed by means of [125I]-cyanopindolol (ICYP). There was a decrease in the number of beta-receptors after incubation with aspirin in all asthmatic patients with sensitivity. The differences between mean basal (660 +/- 171 receptors/cell) and postincubation (398 +/- 110 receptors/cell) values were significant (p < 0.05). There were also significant differences (p < 0.01) between basal (23.4 +/- 6 pM) and postincubation (15 +/- 5.1 pM) Kd values, which indicates that the affinity of ICYP increased. In the subjects in the other two groups, aspirin both increased and decreased the number of beta-receptors, but the effects were not significant. It is suggested that in patients with sensitivity, aspirin could induce changes in the plasmatic membrane, thus altering beta-receptors or inducing the release of inflammatory mediators that exert their effect upon these receptors.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Pindolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/acetylsalicylic acid lysinate,
http://linkedlifedata.com/resource/pubmed/chemical/cyanopindolol
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1018-9068
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
288-93
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8012645-Adult,
pubmed-meshheading:8012645-Aged,
pubmed-meshheading:8012645-Aspirin,
pubmed-meshheading:8012645-Asthma,
pubmed-meshheading:8012645-Down-Regulation,
pubmed-meshheading:8012645-Drug Hypersensitivity,
pubmed-meshheading:8012645-Female,
pubmed-meshheading:8012645-Humans,
pubmed-meshheading:8012645-Lymphocytes,
pubmed-meshheading:8012645-Lysine,
pubmed-meshheading:8012645-Male,
pubmed-meshheading:8012645-Middle Aged,
pubmed-meshheading:8012645-Pindolol,
pubmed-meshheading:8012645-Receptors, Adrenergic, beta
|
| pubmed:articleTitle |
Effect of aspirin on beta-receptors in lymphocytes from patients with aspirin-induced asthma.
|
| pubmed:affiliation |
Department of Allergology and Clinical Immunology, University Clinic, School of Medicine, University of Navarra, Pamplona, Spain.
|
| pubmed:publicationType |
Journal Article
|