Linked Life Data

8011930

Source:http://linkedlifedata.com/resource/pubmed/id/8011930

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-7-28
pubmed:abstractText
X-ray crystallography can reveal the three-dimensional structure of short fragments of DNA or RNA with unique precision. It provides information concerning both the global helical structure and the geometry of local features such as base-pair stacking patterns and backbone conformation. An analysis of the structures of a family of DNA decamers with related sequences, crystallizing in a number of different lattices, defines the ranges in which conformational parameters can vary in B-DNA helices and shows the correlations between them. Thus, these studies show the static structures and give insight into the mechanics of DNA helices by showing how a change of one local conformational parameter will influence others. Crystal structures are also used to assess the competing influences of nucleotide sequence and environment on the three-dimensional DNA structure. To extrapolate from DNA crystal structures to physical characteristics and function of these molecules in solution or embedded into a defined sequence context remains a major challenge.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0301-4622
pubmed:author
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
157-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Crystallographic studies of DNA helix structure.
pubmed:affiliation
Forschungsgruppe Kristallographie, Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't