Linked Life Data

8011294

Source:http://linkedlifedata.com/resource/pubmed/id/8011294

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-7-27
pubmed:abstractText
Somatic rearrangement of the genes encoding antigen receptors allows the mammalian immune system to produce receptors that can recognize virtually any foreign protein. This rearrangement process also generates nonfunctional antigen receptors as well as receptors that can recognize self-proteins. During thymic development, T cells go through a testing process which ensures that cells expressing useless or harmful antigen receptors do not mature. The selection of T cells in the thymus consists of several components driven by distinct recognition events that have distinct consequences for the cell. T cell selection appears to begin before the rearrangement process is complete. Evidence is emerging that T cells have a developmental checkpoint to make sure that the antigen receptor beta gene is successfully rearranged before development can proceed. This checkpoint also appears to be linked to the regulation of rearrangement and mechanisms to ensure that each cell expresses only one antigen receptor (allelic exclusion). After a T cell has successfully rearranged and expressed both its alpha and beta antigen receptor genes, a second phase of selection occurs. During this phase, T cells with self-reactive antigen receptors are eliminated by negative selection, and T cells that can recognize foreign peptides bound to polymorphic self-MHC molecules are selected to mature (positive selection. How these seemingly incompatible forms of selection both occur is a subject of considerable interest. Positive selection is linked also to the choice between the CD4 helper lineage and the CD8 cytotoxic T cell lineage; the mechanisms by which these two events are linked is an ongoing area of investigation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0732-0582
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-705
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Selective events in T cell development.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California at Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review