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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2B
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pubmed:dateCreated |
1994-7-18
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pubmed:abstractText |
Interleukin-6 (IL-6) was measured with an enzyme-immunoassay in blood samples drawn at diagnosis from 37 patients with endometrial cancer, 36 with cervical cancer, 9 with cervical intraepithelial neoplasia (CIN) and 68 with benign uterine disease. The minimal detectable dose of IL-6 was 3 pg/mL. Detectable serum IL-6 levels were found in 9% of patients with benign uterine diseases, 11% of patients with CIN, 44% of patients with cervical cancer and 11% of patients with endometrial cancer. As regards cervical cancer, serum IL-6 levels > 3 pg/mL were found in 36.0% of 25 patients with stage Ib-IIa disease and in 64% of 11 patients with stage IIb-IV disease. As regards endometrial cancer, serum detectable IL-6 levels were observed in 0% of 30 patients with stage I-II disease and in 57% of 7 patients with stage III-IV disease (p = 0.0005). These preliminary data suggest that IL-6 may be involved in the progression of uterine malignancies.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
735-7
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8010733-Adult,
pubmed-meshheading:8010733-Aged,
pubmed-meshheading:8010733-Aged, 80 and over,
pubmed-meshheading:8010733-Carcinoma,
pubmed-meshheading:8010733-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:8010733-Endometrial Neoplasms,
pubmed-meshheading:8010733-Female,
pubmed-meshheading:8010733-Humans,
pubmed-meshheading:8010733-Immunoenzyme Techniques,
pubmed-meshheading:8010733-Interleukin-6,
pubmed-meshheading:8010733-Middle Aged,
pubmed-meshheading:8010733-Neoplasm Staging,
pubmed-meshheading:8010733-Sensitivity and Specificity,
pubmed-meshheading:8010733-Uterine Cervical Neoplasms,
pubmed-meshheading:8010733-Uterine Diseases,
pubmed-meshheading:8010733-Uterine Neoplasms
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pubmed:articleTitle |
Serum interleukin-6 levels in uterine malignancies. Preliminary data.
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pubmed:affiliation |
Istituto di Medicina Nucleare, Università di Pisa, Italy.
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pubmed:publicationType |
Journal Article
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