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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-7-19
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pubmed:abstractText |
1. Effects of hydrostatic pressure (range 0.1-10 MPa) on the isometric tension of skinned (rabbit psoas) muscle fibres were examined at 12 degrees C and at different levels of Ca2+ activation (pCa range 4-7); the effects on both the steady tension and the tension transients induced by rapid pressure release (< 1 ms) are described. 2. The steady tension was depressed by increased pressure (approximately 1% MPa-1) at a high level of Ca2+ activation (pCa approximately 4) whereas it was potentiated at lower Ca2+ levels (pCa > 6); the effects were reversible. 3. At maximal Ca2+ activation, the tension recovery following pressure release (10 MPa to atmospheric) consisted of a fast (approximately 30 s-1) and a slow (2-3 s-1) phase; the rate and the normalized amplitude (normalized to the steady tension at atmospheric pressure for a particular pCa) of the fast phase were invariant with changes in Ca2+ level. 4. The effects of changing Ca2+ level on the slow phase were complex; its positive amplitude at high Ca2+ levels changed to negative and the rate decreased to approximately 1 s-1 at low Ca2+ levels (pCa > 6.0). 5. Results are discussed in relation to previous studies on the effect of pressure on intact muscle fibres and the actin-myosin interaction. This work supports calcium regulation of cross-bridge recruitment rather than calcium regulation of the rate of a specific step in the cross-bridge cycle.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-10627230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-1403812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-1816380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-1871140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-1953663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2243087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2275960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2455798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2661721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2760190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2892206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-2966401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-3446791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-3663829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-4091793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-6460759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8006815-6930656
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
474
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
283-90
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:8006815-Animals,
pubmed-meshheading:8006815-Atmospheric Pressure,
pubmed-meshheading:8006815-Calcium,
pubmed-meshheading:8006815-Hydrostatic Pressure,
pubmed-meshheading:8006815-Isometric Contraction,
pubmed-meshheading:8006815-Muscle Relaxation,
pubmed-meshheading:8006815-Muscles,
pubmed-meshheading:8006815-Psoas Muscles,
pubmed-meshheading:8006815-Rabbits,
pubmed-meshheading:8006815-Recruitment, Neurophysiological
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pubmed:year |
1994
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pubmed:articleTitle |
Contractile activation and force generation in skinned rabbit muscle fibres: effects of hydrostatic pressure.
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pubmed:affiliation |
Department of Physiology, School of Medicine, University of Bristol.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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